Though incredible gains have been made to control HIV and AIDS epidemics, AIDS-related deaths have plateaued. Those facing the greatest risk of mortality and morbidity are the individuals living with advanced HIV disease. The burden of advanced HIV disease is significant and the health risks faced by those living with HIV are great. The Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) has been working to build innovative models to respond to the health needs of all individuals at risk of, or infected with HIV, including those diagnosed with advanced HIV disease. This fact sheet highlights why advanced HIV disease requires urgent attention, and health programming and services that can prevent and treat advanced disease.
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Malawi landscape
Poster
Twenty-Four-Month Survival Among Patients with Cryptococcal Antigenemia Enrolled in Malawi’s Advanced HIV Disease Program: A Retrospective Cohort Study
Published August 2026
We assessed 24-month survival and factors associated with mortality among AHD clients with cryptococcal antigenemia enrolled in Malawi’s AHD program.
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Topics:
Advanced HIV Disease (AHD)
Countries:
Malawi
Poster
From Mortality Review to Mortality Reduction: The Importance of Embedding Routine Pediatric HIV Death Audits in Tanzania
Published August 2026
We assessed the implementation of standardized pediatric mortality audits and associated programmatic responses on mortality trends among CLHIV in Tanzania.
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Topics:
Pediatric HIV,
Research
Countries:
Tanzania
A cough monitor having a review meeting with a mother at ndhiwa Subcounty hospital.EGPAF worked in partnership with ministry of health Homabay county to implement CaP TB (Catalyzing Pediatric TB). CaP TB sought to reduce childhood illness and deaths due to TB in Homabay and Turkana counties by developing, implementing and documenting innovative models of care and catalyzing their wide-scale implementation to improve case detection and treatment.
Journal Articles
Innovations to improve identification of TB and SARS-CoV-2 infections in sub-Saharan Africa
Published July 2026
This supplement highlights research on integrated COVID-19 and tuberculosis services to improve diagnosis, care, and health system resilience in Cameroon and Kenya.
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Topics:
Research,
Tuberculosis (TB)
Countries:
Global