Journal Articles | August 2023

Strengthening the Evidence

Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini

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Overview

Birth defect surveillance in Eswatini in 2020–2021 identified 0.80% defects (197/24 599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4902 women on dolutegravir preconception, 17 285 HIV-negative women, and 1320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.

Michelle M Gill, Philisiwe Khumalo, Caspian Chouraya, Mthokozisi Kunene, Futhi Dlamini, Heather J Hoffman, Angela E Scheuerle, Bonisile Nhlabatsi, Wiseman Mngometulu, Ntombikayise Dlamini-Madlopha, Nompumelelo Mthunzi, Lynne Mofenson, Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini, Open Forum Infectious Diseases, Volume 10, Issue 9, September 2023, ofad441, https://doi.org/10.1093/ofid/ofad441

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Eswatini

Topics:

Prevention of Mother-to-Child Transmission