Ideas & Impact › Resources › Human Immunodeficiency Virus Antiretroviral Resistance and Transmission in Mother-Infant Pairs Enrolled in a Large Perinatal Study

This study evaluated the prevalence and the effect of antiretroviral drug-associated resistance mutations (DRMs) in previously untreated mother-infant pairs. Through a case-control design, the research team evaluated DRMs as a predictor of mother-to-child HIV transmission (MTCT) in specimens obtained from mother-infant pairs. Results indicated that preexisting DRMs were common in untreated HIV-infected pregnant women, but did not increase the risk of HIV MTCT.

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Poster

Programmatic Gaps Under Option B+: Factors Associated with Residual Vertical HIV Transmission in Malawi, 2020 – 2024

Published August 2026

In our study, vertical transmission was strongly associated with lack of ART at delivery and unsuppressed maternal viral load.

Topics:

Prevention of Mother-to-Child Transmission (PMTCT),

Research

Countries:

Malawi

Journal Articles

Unfinished Business in Elimination of Vertical HIV Transmission and Ensuring HIV-Free Survival

Published June 2026

Journal of the International AIDS Society: Volume 29, Issue S1 How do we finally end pediatric HIV? A new supplement from the Journal of the International AIDS Society unpacks this vital question. Co-edited by EGPAF’s Lynne Mofenson, with a commentary from Team EGPAF, the supplement describes the innovations that can finally eliminate vertical transmission and ensure children […]

Topics:

HIV,

Prevention of Mother-to-Child Transmission (PMTCT)

Countries:

Global

Journal Articles

Breastfeeding, Antiretroviral Therapy, HIV Transmission, and the HIV Reservoir

Published October 2024

Recommendations on breastfeeding by persons living with HIV (PLWH) have shifted globally over time. Because the absolute risk for HIV transmission through breast milk in the absence of antiretroviral therapy (ART) is as high as 16% to 20%, recommendations for low-resource settings in the early 1990s initially emphasized replacement feeding if acceptable, feasible, affordable, sustainable, […]

Topics:

Prevention of Mother-to-Child Transmission (PMTCT),

Research