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Overview

The first step in improving morbidity and mortality among children living with HIV is the timely and early identification of HIV infection, which must be followed by rapid engagement in care and provision of antiretroviral therapy. However, in 2018, only 59% of HIV-exposed infants received an infant nucleic acid diagnostic test by age 2 months and only 54% of children living with HIV received treatment. Because infant diagnosis requires molecular techniques to detect viral nucleic acid, programs for early diagnosis of infection in infants are more complex than those in adults and often require coordination and management of multiple health facilities as well as logistic, financial, and human resource challenges. These 12 articles highlight the evidence for the use of point-of-care nucleic acid testing in early infant diagnosis and beyond.

Click here to access the full July 1, 2020 – Volume 84 – 1
JAIDS supplement.

Read each article in the supplement below:

Challenges in the Early Infant HIV Diagnosis and Treatment Cascade

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S1-S4, July 1, 2020.

Impact of Routine Point-of-Care Versus Laboratory Testing for Early Infant Diagnosis of HIV: Results From a Multicountry Stepped-Wedge Cluster-Randomized Controlled Trial

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S5-S11, July 1, 2020.

Strengthening Existing Laboratory-Based Systems vs. Investing in Point-of-Care Assays for Early Infant Diagnosis of HIV: A Model-Based Cost-Effectiveness Analysis

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S12-S21, July 1, 2020.

The Cascade of Care From Routine Point-of-Care HIV Testing at Birth: Results From an 18-Months Pilot Program in Eswatini

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S22-S27, July 1, 2020.

Effectiveness of Maternal Transmission Risk Stratification in Identification of Infants for HIV Birth Testing: Lessons From Zimbabwe

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S28-S33, July 1, 2020.

HIV Mother-to-Child Transmission in Cameroon: EID Positivity Yields and Key Risk Factors by Health Service Points After Usage of POC EID Systems

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S34-S40, July 1, 2020.

Acceptability of Routine Point-of-Care Early Infant Diagnosis in Eight African Countries: Findings From a Qualitative Assessment of Clinical and Laboratory Personnel

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S41-S48, July 1, 2020.

“We Need it the Same Day”: A Qualitative Study of Caregivers and Community Members’ Perspectives Toward the Use of Point-of-Care Early Infant Diagnosis

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S49-S55, July 1, 2020.

Building and Sustaining Optimized Diagnostic Networks to Scale-up HIV Viral Load and Early Infant Diagnosis

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S56-S62, July 1, 2020.

Estimating the Cost of Point-of-Care Early Infant Diagnosis in a Program Setting: A Case Study Using Abbott m-PIMA and Cepheid GeneXpert IV in Zimbabwe

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S63-S69, July 1, 2020.

Front-Line Human Resource Time-Use for Early Infant HIV Diagnosis: A Comparative Time-Motion Study at Centralized and Point-of-Care Health Facilities in Zimbabwe

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S70-S77, July 1, 2020.

Use of Point-of-Care Nucleic Acid Tests Beyond Early Infant Diagnosis of HIV: A Retrospective Case Review in Lesotho

JAIDS Journal of Acquired Immune Deficiency Syndromes. 84:S78-S83, July 1, 2020.

The JAIDS supplement and the point-of-care early infant diagnosis (POC EID) project were made possible thanks to Unitaid’s funding and support. Unitaid accelerates access to innovation so that critical health products can reach the people who most need them.