Completed | December 2017

Outcomes of Differentiated Models of Antiretroviral Treatment (ART) Provision

Multi-Month Dispensing (MMD) of ART in Community ART Distribution for Stable HIV-infected Patients

Overview

Country:

Lesotho

Subject Matter:

Adult Testing, Care, and Treatment

This USAID-funded study evaluated the impact and cost-effectiveness of three models of ART provision for stable ART patients in Lesotho. The objectives were to measure patient retention, virological suppression, provider and patient costs, cost-effectiveness, and patient acceptability among stable patients who received ART at intervals of three and six months within community distribution models and to compare them to patients who received ART directly from the clinic at three month intervals.

Data Collection Period: May 2017 – January 2020

  1. Findings published in BMC Public Health, August 2018: “Outcomes of community-based differentiated models of multi-month dispensing of antiretroviral medication among stable HIV-infected patients in Lesotho: a cluster randomised non-inferiority trial protocol“
  2. Findings presented at the 27th Conference on Retroviruses and Opportunistic Infections, March 2020: “Community-based Multimonth Dispensing of ART: A Cluster Randomised Trial in Lesotho“
  3. Findings published in the Journal of Acquired Immune Deficiency Syndrome, November 2020: “Twelve-Month Outcomes of Community-Based Differentiated Models of Multimonth Dispensing of ART Among Stable HIV-Infected Adults in Lesotho: A Cluster-Randomized Noninferiority Trial“
  4. Findings presented at the 28th Conference on Retroviruses and Opportunistic Infections, March 2021: “Community Multimonth ART Provision: Pooled Analysis of 2 Cluster-randomized Trials“
  5. Findings published in the Journal of the International AIDS Society, April 2021: “Economic evaluation of differentiated service delivery models for HIV treatment in Lesotho: costs to providers and patients“
  6. Findings published in the Journal of Acquired Immune Deficiency Syndrome, September 2021: “Out-of-Facility Multimonth Dispensing of Antiretroviral Treatment: A Pooled Analysis Using Individual Patient Data From Cluster-Randomized Trials in Southern Africa“
  7. Findings published in the Journal of the International AIDS Society, October 2021: “Community-based differentiated service delivery models incorporating multi-month dispensing of antiretroviral treatment for newly stable people living with HIV receiving single annual clinical visits: a pooled analysis of two cluster-randomized trials in southern Africa“

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