Ideas & Impact › Resources › Advanced HIV Disease Brief

Though incredible gains have been made to control HIV and AIDS epidemics, AIDS-related deaths have plateaued. Those facing the greatest risk of mortality and morbidity are the individuals living with advanced HIV disease. The burden of advanced HIV disease is significant and the health risks faced by those living with HIV are great. The Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) has been working to build innovative models to respond to the health needs of all individuals at risk of, or infected with HIV, including those diagnosed with advanced HIV disease. This fact sheet highlights why advanced HIV disease requires urgent attention, and health programming and services that can prevent and treat advanced disease.

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Issue Briefs

Accelerating Progress to Ending Pediatric HIV

Published March 2026

We are at a critical inflection point for children affected by HIV. In 2024 alone, 120,000 children were newly infected, and, without timely treatment, half of HIV positive infants will not reach their second birthday. Children remain left behind—a child with HIV is 6 times more likely to die than an adult without timely diagnosis. […]

Topics:

HIV,

Pediatric HIV

Countries:

Global

Resource

Protecting Lives, Sustaining Progress

Published March 2026

The following landscape analysis of maternal and child health, HIV prevention, diagnosis, and treatment, and the historic strength of U.S. leadership in global aid provides an overview of these key areas of global health and recommendations for U.S. Congressional engagement and prioritization.

Topics:

Advocacy,

Children,

Global Health Security,

Health System Strengthening,

HIV,

Maternal and Child Health,

Mothers and Infants,

Women

Journal Articles

Tuberculosis Preventive Treatment Uptake Among Patients Initiating Antiretroviral Therapy in Malawi: Children Left Behind

Published November 2025

Background: Tuberculosis preventive treatment (TPT) is recommended for people living with HIV (PLHIV) to reduce the tuberculosis (TB) incidence in regions with a high prevalence of TB. We evaluated the uptake and completion of TPT among newly initiated antiretroviral therapy (ART) patients in a programme setting in Malawi. Objectives: To describe TPT initiation and completion rates, and […]

Topics:

Pediatric Tuberculosis (TB),

Tuberculosis (TB)

Countries:

Malawi