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Journal Articles

Follow-Up Outcomes of Children, Adolescents, and Young People on Darunavir-Based Third-Line Antiretroviral Therapy

Published October 30, 2024

Background: We assessed clinical outcomes among children, adolescents, and people younger than 25 years on darunavir-based antiretroviral therapy (ART) in 9 sub-Saharan African countries. Setting: Third-line ART centers in Cameroon, Eswatini, Kenya, Lesotho, Nigeria, Rwanda, Uganda, Zambia, and Zimbabwe. Methods: From January 2019 to December 2022, we collected data from a cohort of…

Topics:

Adolescents,

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Rwanda,

Uganda,

Zambia,

Zimbabwe

Journal Articles

Breastfeeding, Antiretroviral Therapy, HIV Transmission, and the HIV Reservoir

Published October 8, 2024

Recommendations on breastfeeding by persons living with HIV (PLWH) have shifted globally over time. Because the absolute risk for HIV transmission through breast milk in the absence of antiretroviral therapy (ART) is as high as 16% to 20%, recommendations for low-resource settings in the early 1990s initially emphasized replacement feeding…

Topics:

Prevention of Mother-to-Child Transmission (PMTCT),

Research

Issue Briefs

Building a Future of Health

Published October 2, 2024

An Unspoken Crisis: Children Are Being Left Behind In 2022, one child died every six seconds. The causes of most of those deaths were preventable. This is unacceptable. Whereas countries have the tools and knowledge to end preventable deaths and suffering in children, children face inequalities in access to health…

Topics:

Pediatric HIV,

Tuberculosis (TB)

Little girl's hands

Issue Briefs

Building Trust for Global Health

Published October 2, 2024

Most causes of deaths in children could be prevented with effective treatment and interventions that are feasible for implementation, even in resource-constrained settings. However, appropriate medicines to save and improve the lives of infants and children often do not exist, are unavailable, or are not quality assured. This puts children’s…

Topics:

HIV,

Pediatric HIV

Resource

Looking Forward

Published September 15, 2024

Topics:

Adolescents,

Pediatric HIV,

Prevention of Mother-to-Child Transmission (PMTCT)

Journal Articles

The Rollout of Paediatric Dolutegravir and Virological Outcomes Among Children Living with HIV in Mozambique

Published July 30, 2024

Background In 2022, Mozambique introduced Dolutegravir 10mg (pDTG), as part of paediatric antiretroviral therapy for children weighing < 20 kg. Understanding real-world challenges during national rollout can strengthen health systems in resource-limited settings. Objectives We described the transition rate to, and new initiation of, pDTG, viral load suppression (VLS)…

Topics:

Pediatric HIV,

Research

Countries:

Mozambique

Project Brief

Building Health Systems Capacity Reaching HIV Epidemic Viral Suppression Targets in All Children and Adolescents

Published July 17, 2024

Great progress has been made by many countries in reaching the UN 95-95-95 targets for HIV epidemic control, and several countries are approaching or have achieved them. However, children and adolescents living with HIV (CALHIV) consistently fall behind adults in reaching these targets, and the third 95 target of sustained…

Topics:

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Republic of the Congo,

Rwanda,

Uganda,

Zambia,

Zimbabwe

Project Brief

Building Health Systems Capacity to Manage Pediatric HIV

Published July 17, 2024

As countries work towards the UNAIDS 95-95-95 goals for HIV epidemic control, the third 95 of viral suppression becomes pivotal, especially for children and adolescents living with HIV (CALHIV). An estimated 10-20% of CALHIV have an unsuppressed viral load (VL) on their current first- or second-line antiretroviral therapy (ART)…

Topics:

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Republic of the Congo,

Rwanda,

Uganda,

Zambia,

Zimbabwe

Journal Articles

Lessons from a Decade of Adult Vaccine Rollout in Low- and Middle-income Countries

Published June 27, 2024

Introduction The historical focus of vaccines on child health coupled with the advent of novel vaccines targeting adult populations necessitates exploring strategies for adult vaccine implementation. Areas covered This scoping review extracts insights from the past decade’s experiences introducing adult vaccines in low- and middle-income countries. Among 25 papers reviewed,…

Topics:

Research