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Journal Articles

Follow-Up Outcomes of Children, Adolescents, and Young People on Darunavir-Based Third-Line Antiretroviral Therapy

Published October 30, 2024

Background: We assessed clinical outcomes among children, adolescents, and people younger than 25 years on darunavir-based antiretroviral therapy (ART) in 9 sub-Saharan African countries. Setting: Third-line ART centers in Cameroon, Eswatini, Kenya, Lesotho, Nigeria, Rwanda, Uganda, Zambia, and Zimbabwe. Methods: From January 2019 to December 2022, we collected data from a cohort of…

Topics:

Adolescents,

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Rwanda,

Uganda,

Zambia,

Zimbabwe

Little girl's hands

Issue Briefs

Building Trust for Global Health

Published October 2, 2024

Most causes of deaths in children could be prevented with effective treatment and interventions that are feasible for implementation, even in resource-constrained settings. However, appropriate medicines to save and improve the lives of infants and children often do not exist, are unavailable, or are not quality assured. This puts children’s…

Topics:

HIV,

Pediatric HIV

Issue Briefs

Building a Future of Health

Published October 2, 2024

An Unspoken Crisis: Children Are Being Left Behind In 2022, one child died every six seconds. The causes of most of those deaths were preventable. This is unacceptable. Whereas countries have the tools and knowledge to end preventable deaths and suffering in children, children face inequalities in access to health…

Topics:

Pediatric HIV,

Tuberculosis (TB)

Resource

Looking Forward

Published September 15, 2024

Topics:

Adolescents,

Pediatric HIV,

Prevention of Mother-to-Child Transmission (PMTCT)

Journal Articles

The Rollout of Paediatric Dolutegravir and Virological Outcomes Among Children Living with HIV in Mozambique

Published July 30, 2024

Background In 2022, Mozambique introduced Dolutegravir 10mg (pDTG), as part of paediatric antiretroviral therapy for children weighing < 20 kg. Understanding real-world challenges during national rollout can strengthen health systems in resource-limited settings. Objectives We described the transition rate to, and new initiation of, pDTG, viral load suppression (VLS)…

Topics:

Pediatric HIV,

Research

Countries:

Mozambique

Project Brief

Building Health Systems Capacity to Manage Pediatric HIV

Published July 17, 2024

As countries work towards the UNAIDS 95-95-95 goals for HIV epidemic control, the third 95 of viral suppression becomes pivotal, especially for children and adolescents living with HIV (CALHIV). An estimated 10-20% of CALHIV have an unsuppressed viral load (VL) on their current first- or second-line antiretroviral therapy (ART)…

Topics:

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Republic of the Congo,

Rwanda,

Uganda,

Zambia,

Zimbabwe

Project Brief

Building Health Systems Capacity Reaching HIV Epidemic Viral Suppression Targets in All Children and Adolescents

Published July 17, 2024

Great progress has been made by many countries in reaching the UN 95-95-95 targets for HIV epidemic control, and several countries are approaching or have achieved them. However, children and adolescents living with HIV (CALHIV) consistently fall behind adults in reaching these targets, and the third 95 target of sustained…

Topics:

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Republic of the Congo,

Rwanda,

Uganda,

Zambia,

Zimbabwe

Journal Articles

Consistency of Multi-Month Antiretroviral Therapy Dispensing and Association with Viral Load Coverage Among Pediatric Clients Living with HIV in Mozambique

Published June 25, 2024

Abstract With the increase in uptake of multi-month antiretroviral therapy dispensing (MMD) for children, little is known about consistency of MMD receipt over time and its association with virological outcomes. This analysis aims to assess the uptake of 3-month MMD among children, consistent receipt of MMD after uptake, and clinical…

Topics:

Differentiated Service Delivery,

Pediatric HIV,

Research

Countries:

Mozambique

Technical Briefs

Technical Brief on Paediatric HIV Case-Finding

Published May 6, 2024

Despite global progress in HIV treatment for children, the gap between adult and paediatric treatment coverage continues to widen. This gap is driven primarily by barriers to HIV diagnosis in children, but in the past decade those barriers have shifted. At the start of the epidemic, the lack of access…

Topics:

Pediatric HIV