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Journal Articles

An integrated, multidisciplinary management team intervention to improve patient‑centeredness, HIV, and maternal‑child outcomes in Lesotho

Published December 22, 2024

Background Reducing perinatal HIV transmission and optimizing maternal and child health (MCH) outcomes in high HIV prevalence settings is an urgent, but complex, priority. Extant interventions over-emphasize individual-level provider and patient behaviors, and neglect critical health systems-level changes. The ‘Integrated Management Team to Improve Maternal-Child Outcomes (IMPROVE)’ study implemented a…

Topics:

Maternal and Child Health

Countries:

Lesotho

Journal Articles

Follow-Up Outcomes of Children, Adolescents, and Young People on Darunavir-Based Third-Line Antiretroviral Therapy

Published October 30, 2024

Background: We assessed clinical outcomes among children, adolescents, and people younger than 25 years on darunavir-based antiretroviral therapy (ART) in 9 sub-Saharan African countries. Setting: Third-line ART centers in Cameroon, Eswatini, Kenya, Lesotho, Nigeria, Rwanda, Uganda, Zambia, and Zimbabwe. Methods: From January 2019 to December 2022, we collected data from a cohort of…

Topics:

Adolescents,

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Rwanda,

Uganda,

Zambia,

Zimbabwe

Journal Articles

A Longitudinal Assessment of Interruptions in HIV Clinic Visits and Virologic Failure among Pregnant and Postpartum Women in the Kabeho Study

Published October 30, 2024

Background: Antiretroviral therapy (ART) for women with HIV is recommended for life, yet most studies measure retention in HIV care and treatment as a binary outcome rather than patterns of intermittent clinic attendance. Pregnancy and the post-partum period are critical times to study interruptions in care, as retention among these women…

Topics:

Maternal and Child Health

Countries:

Rwanda

Journal Articles

Integrating SARS-CoV-2 rapid antigen testing in maternal, neonatal and child health, HIV, and TB clinics in Kenya and Cameroon

Published October 30, 2024

Introduction: Early diagnosis of SARS-CoV-2 infection is key to preventing severe disease and poor outcomes in vulnerable populations, such as pregnant women and people living with HIV or diagnosed with tuberculosis (TB). We assessed outcomes achieved with the integration of SARS-CoV-2 antigen-detecting rapid diagnostic testing (Ag-RDT) into maternal, neonatal and…

Topics:

Global Health Security,

Maternal and Child Health

Countries:

Cameroon,

Kenya

Little girl's hands

Issue Briefs

Building Trust for Global Health

Published October 2, 2024

Most causes of deaths in children could be prevented with effective treatment and interventions that are feasible for implementation, even in resource-constrained settings. However, appropriate medicines to save and improve the lives of infants and children often do not exist, are unavailable, or are not quality assured. This puts children’s…

Topics:

HIV,

Pediatric HIV

Issue Briefs

Building a Future of Health

Published October 2, 2024

An Unspoken Crisis: Children Are Being Left Behind In 2022, one child died every six seconds. The causes of most of those deaths were preventable. This is unacceptable. Whereas countries have the tools and knowledge to end preventable deaths and suffering in children, children face inequalities in access to health…

Topics:

Pediatric HIV,

Tuberculosis (TB)

Resource

Looking Forward

Published September 15, 2024

Topics:

Adolescents,

Pediatric HIV,

Prevention of Mother-to-Child Transmission (PMTCT)

Journal Articles

The Rollout of Paediatric Dolutegravir and Virological Outcomes Among Children Living with HIV in Mozambique

Published July 30, 2024

Background In 2022, Mozambique introduced Dolutegravir 10mg (pDTG), as part of paediatric antiretroviral therapy for children weighing < 20 kg. Understanding real-world challenges during national rollout can strengthen health systems in resource-limited settings. Objectives We described the transition rate to, and new initiation of, pDTG, viral load suppression (VLS)…

Topics:

Pediatric HIV,

Research

Countries:

Mozambique

Project Brief

Building Health Systems Capacity Reaching HIV Epidemic Viral Suppression Targets in All Children and Adolescents

Published July 17, 2024

Great progress has been made by many countries in reaching the UN 95-95-95 targets for HIV epidemic control, and several countries are approaching or have achieved them. However, children and adolescents living with HIV (CALHIV) consistently fall behind adults in reaching these targets, and the third 95 target of sustained…

Topics:

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Republic of the Congo,

Rwanda,

Uganda,

Zambia,

Zimbabwe