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Issue Briefs
Accelerating Progress to Ending Pediatric HIV
Published March 30, 2026
We are at a critical inflection point for children affected by HIV. In 2024 alone, 120,000 children were newly infected, and, without timely treatment, half of HIV positive infants will not reach their second birthday. Children remain left behind—a child with HIV is 6 times more likely to die than…
Topics:
HIV,
Pediatric HIV
Countries:
Global
Fact Sheets
Resource
Protecting Lives, Sustaining Progress
Published March 15, 2026
The following landscape analysis of maternal and child health, HIV prevention, diagnosis, and treatment, and the historic strength of U.S. leadership in global aid provides an overview of these key areas of global health and recommendations for U.S. Congressional engagement and prioritization.
Topics:
Advocacy,
Children,
Global Health Security,
Health System Strengthening,
HIV,
Maternal and Child Health,
Mothers and Infants,
Women
Countries:
Global,
United States
Journal Articles
HIV Drug Resistance Profile in Clients Experiencing Treatment Failure After the Transition to a Dolutegravir-Based First-Line Antiretroviral Treatment Regimen in Mozambique
Published January 8, 2025
Real-world data on HIV drug resistance (HIVDR) after transitioning to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD) are limited. We assessed HIVDR rates and patterns in clients with virological failure (VF) after switching from an NNRTI-based regimen to TLD. A cross-sectional study was conducted in Gaza, Mozambique (August 2021–February 2022), including adults on…
Topics:
HIV
Countries:
Mozambique
Journal Articles
Clients’ and providers’ perspectives in informing a digital health intervention to improve linkage to care after Index HIV self-testing in Hai and Moshi Districts, Tanzania
Published October 31, 2024
Background Digital health interventions have the potential to improve linkage to care after HIV self-testing (HIVST). This study aimed to understand clients’ and providers’ perceptions of benefits, and barriers of a digital health intervention designed to improve linkage to care after HIV self-testing in Tanzania. Methods This exploratory qualitative research…
Topics:
HIV
Countries:
Tanzania
Journal Articles
Follow-Up Outcomes of Children, Adolescents, and Young People on Darunavir-Based Third-Line Antiretroviral Therapy
Published October 30, 2024
Background: We assessed clinical outcomes among children, adolescents, and people younger than 25 years on darunavir-based antiretroviral therapy (ART) in 9 sub-Saharan African countries. Setting: Third-line ART centers in Cameroon, Eswatini, Kenya, Lesotho, Nigeria, Rwanda, Uganda, Zambia, and Zimbabwe. Methods: From January 2019 to December 2022, we collected data from a cohort of…
Topics:
Adolescents,
Pediatric HIV
Countries:
Cameroon,
Eswatini,
Kenya,
Lesotho,
Nigeria,
Rwanda,
Uganda,
Zambia,
Zimbabwe
Journal Articles
Breastfeeding, Antiretroviral Therapy, HIV Transmission, and the HIV Reservoir
Published October 8, 2024
Recommendations on breastfeeding by persons living with HIV (PLWH) have shifted globally over time. Because the absolute risk for HIV transmission through breast milk in the absence of antiretroviral therapy (ART) is as high as 16% to 20%, recommendations for low-resource settings in the early 1990s initially emphasized replacement feeding…
Topics:
Prevention of Mother-to-Child Transmission (PMTCT),
Research
Issue Briefs
Building Trust for Global Health
Published October 2, 2024
Most causes of deaths in children could be prevented with effective treatment and interventions that are feasible for implementation, even in resource-constrained settings. However, appropriate medicines to save and improve the lives of infants and children often do not exist, are unavailable, or are not quality assured. This puts children’s…
Topics:
HIV,
Pediatric HIV
Issue Briefs
Building a Future of Health
Published October 2, 2024
An Unspoken Crisis: Children Are Being Left Behind In 2022, one child died every six seconds. The causes of most of those deaths were preventable. This is unacceptable. Whereas countries have the tools and knowledge to end preventable deaths and suffering in children, children face inequalities in access to health…
Topics:
Pediatric HIV,
Tuberculosis (TB)