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Issue Briefs
Accelerating Progress to Ending Pediatric HIV
Published March 30, 2026
We are at a critical inflection point for children affected by HIV. In 2024 alone, 120,000 children were newly infected, and, without timely treatment, half of HIV positive infants will not reach their second birthday. Children remain left behind—a child with HIV is 6 times more likely to die than…
Topics:
HIV,
Pediatric HIV
Countries:
Global
Fact Sheets
Resource
Protecting Lives, Sustaining Progress
Published March 15, 2026
The following landscape analysis of maternal and child health, HIV prevention, diagnosis, and treatment, and the historic strength of U.S. leadership in global aid provides an overview of these key areas of global health and recommendations for U.S. Congressional engagement and prioritization.
Topics:
Advocacy,
Children,
Global Health Security,
Health System Strengthening,
HIV,
Maternal and Child Health,
Mothers and Infants,
Women
Countries:
Global,
United States
Journal Articles
Tuberculosis Preventive Treatment Uptake Among Patients Initiating Antiretroviral Therapy in Malawi: Children Left Behind
Published November 24, 2025
Background: Tuberculosis preventive treatment (TPT) is recommended for people living with HIV (PLHIV) to reduce the tuberculosis (TB) incidence in regions with a high prevalence of TB. We evaluated the uptake and completion of TPT among newly initiated antiretroviral therapy (ART) patients in a programme setting in Malawi. Objectives: To describe TPT…
Topics:
Pediatric Tuberculosis (TB),
Tuberculosis (TB)
Countries:
Malawi
Journal Articles
HIV Drug Resistance Profile in Clients Experiencing Treatment Failure After the Transition to a Dolutegravir-Based First-Line Antiretroviral Treatment Regimen in Mozambique
Published January 8, 2025
Real-world data on HIV drug resistance (HIVDR) after transitioning to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD) are limited. We assessed HIVDR rates and patterns in clients with virological failure (VF) after switching from an NNRTI-based regimen to TLD. A cross-sectional study was conducted in Gaza, Mozambique (August 2021–February 2022), including adults on…
Topics:
HIV
Countries:
Mozambique
Journal Articles
Examining teen club attendance and viral load suppression among adolescents under differentiated HIV care in Malawi
Published January 5, 2025
Background In Malawi, compared to adults, adolescents have higher rates of high HIV viremia and poorer antiretroviral therapy (ART) outcomes. The Ministry of Health, supported by the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF), implemented the provision of differentiated care clubs for adolescents living with HIV (ALHIV), called “teen clubs,” to…
Topics:
Adolescents
Countries:
Malawi
Journal Articles
Improving HIV testing and retention among adolescents and youths
Published December 19, 2024
Adolescents and youth living with HIV (AYLHIV) often face significant challenges in HIV care. Elizabeth Glaser Pediatric AIDS Foundation in Malawi implemented the Red-Carpet Program (RCP) to provide fast-tracked services for AYLHIV in care.This study aimed to assess the effect of RCP on Provider-Initiated HIV testing, linkage to care and…
Topics:
Adolescents
Countries:
Malawi
Journal Articles
Effect of integrating paediatric tuberculosis services into child healthcare services on case detection in Africa
Published December 18, 2024
Introduction Paediatric tuberculosis (TB) underdiagnosis is a critical concern. The INPUT stepped-wedge cluster-randomised trial assessed the impact of integrating child TB services into child healthcare on TB case detection among children under age 5 years. Methods We compared the standard of care, providing TB care in specific TB clinics…
Topics:
Tuberculosis (TB)
Countries:
Cameroon,
Kenya
Program Tools
Breakthrough Champion Advocacy Toolkit
Published December 1, 2024
This Breakthrough Champion Advocacy Toolkit is targeted towards strengthening the capacity of adolescents and youth to advocate for addressing HIV treatment inequalities to end AIDS. The Toolkit serves as a training manual for the Breakthrough Partnership’s adolescent champions to develop advocacy skills and gain knowledge about HIV treatment gaps and…
Topics:
Adolescents
Countries:
Mozambique,
Nigeria,
Uganda