In 2025, we continued our transformational work.
This year was marked by disruptions, but we remained committed to our mission. Across Sub-Saharan Africa, EGPAF staff worked tirelessly to provide prevention, testing, care, and treatment services to children and their families.
Preventing Mother-to-Child Transmission
607,512 pregnant women were supported with prevention of mother-to-child transmission services across clinics supported by EGPAF in 2025.
Core to our mission is preventing mother-to-child or vertical transmission of HIV. When mothers living with HIV have access to prevention of mother-to-child transmission (PMTCT) services, they can reduce their risk of passing the virus to their babies to less than 2%.
Services include testing, initiation to treatment, supporting treatment adherence, and diagnostics to support babies exposed to HIV through pregnancy and breastfeeding. We also continued strengthening the retention of mother-baby pairs in care through treatment management, adherence, and psychosocial support (PSS).
Over the course of the year, our team supported and tested over 30,000 infants exposed to HIV. Our programs initiated 392 HIV-positive infants under 12 months of age onto lifesaving treatment.
Finding the Missing Children
310,873 children (0-14 years of age) at risk of HIV were tested across programs supported by EGPAF in 2025.
Before children living with HIV can be connected with lifesaving treatment, they must know their HIV status. Today, approximately one third of children living with HIV do not know their status.
Children are missed when their mother is not retained in PMTCT services or if the mother seroconverts during breastfeeding. Actively screening and testing children at risk is an important step to close the gap in case finding. Through our pediatric testing programs, 1,813 children were identified as HIV-positive and directed to treatment.
Providing Lifesaving Treatment
800,000 people, including 22,213 children, access lifesaving antiretroviral therapy through EGPAF-supported programs in 2025.
EGPAF improves antiretroviral therapy (ART) coverage and quality of care by optimizing antiretroviral (ARV) regimens. Our teams scale up differentiated service delivery (DSD) models for comprehensive, integrated, and client-centered care.
Children continue to lag behind adults in treatment outcomes. To close the gap in pediatric access to treatment and provide comprehensive care to children, EGPAF has pediatric-focused family care models. We also support healthcare workers’ skills in pediatric treatment through training and mentorship. Over 2,000 children (under 15) were newly started on lifesaving treatment in 2025.
Preventing New Infections
65,320 individuals at high risk of acquiring HIV were provided with pre-exposure prophylaxis (PrEP) across EGPAF programs in 2025.
Preventing new HIV infections is essential to achieving an AIDS-free generation. As new and improved options are available to prevent HIV transmission, EGPAF is at the forefront to ensure individuals at high risk of HIV have information and access options available to them.
Adolescent girls and young women (AGYW) in sub-Saharan Africa face disproportionate risks, being 5–14x more likely to acquire HIV than their male peers. Our programs focus on closing this gap and understanding the unique needs of AGYW. 20,000 at-risk adolescent girls and young women (15-24 years old) were newly enrolled on PrEP this year.
We also provided over 9,000 pregnant and breastfeeding women with PrEP to protect themselves and their children from HIV.
Achieving Viral Suppression
95% of all patients across EGPAF programs are virally suppressed in 2025.
When a person living with HIV is virally suppressed, he or she is less at risk of other opportunistic infections, like tuberculosis, advanced HIV disease, or ultimately, death from HIV-related causes. Viral suppression is also a key prevention strategy, as people living with HIV with an undetectable viral load cannot transmit to others.
Viral load suppression is not uniform across age groups, and it is often lower for children and adolescents. 83% of children (0-14) are virally suppressed across EGPAF programs. Patient and caregiver education, psychosocial support, and differentiated service delivery are all examples of support programs designed to help improve viral suppression among children.
Helping Families Thrive Beyond HIV
People living with HIV often face health concerns beyond HIV. By providing integrated care, we can ensure families receive the care they need to thrive.
Tuberculosis (TB) is a leading cause of death for people living with HIV. EGPAF has strengthened TB case identification, diagnosis, treatment, as well as TB preventive treatment.
In 2025, EGPAF screened nearly 750,000 patients on ART for TB, including over 21,000 children under the age of 15. There were over 38,000 new or relapsed cases of TB documented in 2025, with 8,736 of those being HIV-positive TB cases. We started over 5,000 ART patients on TB treatment.
Cervical cancer remains a leading cause of death worldwide, claiming more than 350,000 lives annually. The burden is disproportionately high in low- and middle-income countries, where 85% of deaths occur. Women living with HIV face an especially elevated risk, yet gaps in prevention, screening, and treatment persist.
EGPAF supported public health facilities to provide screening, diagnosis and treatment services for cervical cancer. In 2025, EGPAF screened over 104,000 HIV-positive women for cervical cancer. Of those screened, 2,594 were identified as positive and eligible for cryotherapy, thermocoagulation, or LEEP. In 2025, 2,170 HIV-positive women were provided treatment for precancerous cervical lesions through cryotherapy, thermocoagulation, or LEEP.
Impact Doesn’t Happen Alone
Help Us Continue This Transformational Work
Together, we can provide lifesaving prevention, testing, care, and treatment to children and families impacted by HIV.
