Journal Articles

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Detectable Viral Load in Late Pregnancy among Women in the Rwanda Option B+ PMTCT Program: Enrollment Results from the Kabeho Study

This study explored the extent of viral suppression from a prevention of mother-to-child transmission of HIV program in Rwanda  among women enrolled in the Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV (Kabeho) Study.

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Cluster-Randomized Controlled Study of SMS Text Messages for Prevention of Mother-to-Child Transmission of HIV in Rural Kenya

By Kassaye, Ong’ech, Sirengo, Kose, Matu, McOdida, Simiyu, Syengo, Muthama, Machekano5

Antiretroviral medications are key for prevention of mother-to-child transmission (PMTCT) of HIV, and transmission mitigation is affected by service delivery, adherence, and retention.

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Improving estimates of children living with HIV from the Spectrum AIDS Impact Model

By Mahy, Mary; Penazzato, Martina; Ciaranello, Andrea; Mofenson, Lynne; Yianoutsos, Constantin; Davies, Mary-Ann; Stover, John

Estimated numbers of children living with HIV determine programmatic and treatment needs. This paper explains the changes made to the UNAIDS estimates between 2015 and 2016 and describe the challenges around these estimates.

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Tenofovir Disoproxil Fumarate Safety for Women and their Infants During Pregnancy and Breastfeeding: Systematic Review

By Mofenson, Baggaley, Mameletzis

Pregnant/lactating women in some sub-Saharan Africa settings are at substantial risk of HIV acquisition and could benefit from preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF), but safety data in pregnancy/lactation are limited.

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Tenofovir Pre-Exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now

By Lynne M. Mofenson

In this Perspective, Lynne Mofenson discusses the implications of Mugwanya and colleagues' findings for protection of women against HIV infection during breastfeeding.

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Tenofovir Pre-Exposure Prophylaxis for Pregnant and Breastfeeding Women at Risk of HIV Infection: The Time is Now

By Lynne M. Mofenson

In this Perspective, Lynne Mofenson discusses the implications of Mugwanya and colleagues' findings for protection of women against HIV infection during breastfeeding.

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Diagnosis of HIV Infection During Early Infancy: How Early Is Early Enough?

By L. M. Mofenson

Diagnosis of HIV infection during early infancy (commonly known as “early infant HIV diagnosis” [EID]) is critical because HIV disease progression is much more rapid in children than adults, with mortality as high as 68% by age 2 years in infants with perinatal infection (acquired in utero or during the intrapartum period), with much of this risk occurring in the first few months of life. 

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Timing of initiation of antiretroviral therapy and adverse pregnancy outcomes: a systematic review and meta-analysis

By Uthman, Nachega, Anderson, Kanters, Mills, Renaud, Essajee, Doherty, Mofenson

Although lifelong combination antiretroviral therapy (ART) is recommended for all individuals with HIV, few data exist for pregnancy outcomes associated with ART initiation before conception. This study assesses adverse pregnancy outcomes associated with ART initiated before conception compared with that of ART started after conception.

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From policy to action: how to operationalize the treatment for all agenda

By Francesca Celletti, Jennifer Cohn, Catherine Connor, Stephen Lee, Anja Giphart and Julio Montaner

This article proposes the development and adoption of a differentiated care model as a practical approach to reach TfA and accelerate progress towards the 90–90–90 target.

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Opportunities and challenges in conducting secondary analysis of HIV programmes using data from routine health information systems and personal health information

By Gloyd, Wagenaar, Woelk, Kalibala

Analyses focused on retrospective case reviews of four of the HIV-related studies published in this JIAS supplement. We identify specific opportunities and challenges with respect to the secondary analysis of RHIS and PHI data.

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