Issue Briefs

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Doing more, faster: Preliminary results from the routine use of point-of-care early infant HIV diagnosis in six sub- Saharan African countries

To improve health and to save lives, HIV-infected infants must be diagnosed early, rapidly and efficiently, and immediately initiated on treatment. Yet, current current early infant diagnosis systems in resource- limited countries are challenged at multiple levels of the cascade. 


Quality Products to Deliver Quality Care: Monitoring the Performance of Point-of-Care Nucleic Acid Testing Manufacturers

While coverage of conventional, laboratory-based EID has increased in recent years throughout resource- limited countries, testing could be greatly expanded through the integration of new point-of-care (POC) testing technologies into national EID networks. POC technology ensures that infants are screened on-site, that their caregivers quickly receive their test results and that those who test HIV-positive are rapidly enrolled on lifesaving antiretroviral treatment. 


At What Price? Cost Considerations for Integrating Point-Of-Care Early Infant HIV Diagnosis into National Diagnostic Networks

Infants living with HIV that are not initiated on ART have high mortality rates. This makes early infant diagnosis (EID), prompt return of results and rapid initiation on ART essential.2 Virological testing is the only definitive way to confirm HIV status in infants because of the presence of persisting maternal HIV antibody in children up to 18 months of age. The World Health Organization recommends virological testing at 4–6 weeks of age for HIV-exposed infants and new guidance also states that birth testing may be considered. Ensuring prompt and adequate EID is still a challenge in many HIV endemic countries. Globally, only half of infants born to HIV-infected mothers undergo EID and of these, only half ever receive their test results.


Price Transparency: Point-of-Care Early Infant Diagnosis

Price transparency is critical to better position countries and implementing partners to access the best prices. Without price transparency, countries and implementing partners face ambiguity in negotiations with manufacturers and distributers for product and service agreements. POC EID price transparency can help ensure access to the best offers for all, thus improving affordability and maximizing patient impact in countries. 


Improving Access to HIV Care & Treatment Through Decentralization & Integration in Kenya

This brief focuses on EGPAF’s Pamoja Project in Homabay in the four sub-counties in which the project operated, during the period October 2010 to September 2016.

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Lessons from the Advancing Community Level Action for Improved Maternal and Child Health and PMTCT (Project ACCLAIM).



This brief highlights EGPAF’s extensive work in the field of clinical and operations research around pediatric HIV. The brief describes our history in research, our research accomplishments, current research activities and our internationally-recognized staff and research leaders.


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