Pregnancy outcomes and birth defects from an antiretroviral drug safety registry for women in South Africa and Zambia

Background: We assessed clinical outcomes among children, adolescents, and people younger than 25 years on darunavir-based antiretroviral therapy (ART) in 9 sub-Saharan African countries. Setting: Third-line ART centers in Cameroon, Eswatini, Kenya, Lesotho, Nigeria, Rwanda, Uganda, Zambia, and Zimbabwe. Methods: From January 2019 to December 2022, we collected data from a cohort of children, adolescents, and young people […]

Recommendations on breastfeeding by persons living with HIV (PLWH) have shifted globally over time. Because the absolute risk for HIV transmission through breast milk in the absence of antiretroviral therapy (ART) is as high as 16% to 20%, recommendations for low-resource settings in the early 1990s initially emphasized replacement feeding if acceptable, feasible, affordable, sustainable, […]

The urgency of addressing the health needs of children has never been more pressing. Despite significant gains in preventing vertical transmission of HIV, progress has stalled. New HIV infections in children continue to be unacceptably high: In 2023, there were approximately 120,000 new HIV infections among children under five years old. This represents a significant […]