Ideas & Impact › Resources › Human Immunodeficiency Virus Antiretroviral Resistance and Transmission in Mother-Infant Pairs Enrolled in a Large Perinatal Study

This study evaluated the prevalence and the effect of antiretroviral drug-associated resistance mutations (DRMs) in previously untreated mother-infant pairs. Through a case-control design, the research team evaluated DRMs as a predictor of mother-to-child HIV transmission (MTCT) in specimens obtained from mother-infant pairs. Results indicated that preexisting DRMs were common in untreated HIV-infected pregnant women, but did not increase the risk of HIV MTCT.

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Journal Articles

Breastfeeding, Antiretroviral Therapy, HIV Transmission, and the HIV Reservoir

Published October 2024

Recommendations on breastfeeding by persons living with HIV (PLWH) have shifted globally over time. Because the absolute risk for HIV transmission through breast milk in the absence of antiretroviral therapy (ART) is as high as 16% to 20%, recommendations for low-resource settings in the early 1990s initially emphasized replacement feeding if acceptable, feasible, affordable, sustainable, […]

Topics:

Prevention of Mother-to-Child Transmission (PMTCT),

Research

Issue Briefs

Action Towards a HIV-Free Future

Published October 2024

The urgency of addressing the health needs of children has never been more pressing. Despite significant gains in preventing vertical transmission of HIV, progress has stalled. New HIV infections in children continue to be unacceptably high: In 2023, there were approximately 120,000 new HIV infections among children under five years old. This represents a significant […]

Topics:

Prevention of Mother-to-Child Transmission (PMTCT)

Resource

Looking Forward

Published September 2024

Topics:

Adolescents,

Pediatric HIV,

Prevention of Mother-to-Child Transmission (PMTCT)