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Journal Articles

Tuberculosis Preventive Treatment Uptake Among Patients Initiating Antiretroviral Therapy in Malawi: Children Left Behind

Published November 24, 2025

Background: Tuberculosis preventive treatment (TPT) is recommended for people living with HIV (PLHIV) to reduce the tuberculosis (TB) incidence in regions with a high prevalence of TB. We evaluated the uptake and completion of TPT among newly initiated antiretroviral therapy (ART) patients in a programme setting in Malawi. Objectives: To describe TPT…

Topics:

Pediatric Tuberculosis (TB),

Tuberculosis (TB)

Countries:

Malawi

Journal Articles

Effect of integrating paediatric tuberculosis services into child healthcare services on case detection in Africa

Published December 18, 2024

Introduction Paediatric tuberculosis (TB) underdiagnosis is a critical concern. The INPUT stepped-wedge cluster-randomised trial assessed the impact of integrating child TB services into child healthcare on TB case detection among children under age 5 years. Methods We compared the standard of care, providing TB care in specific TB clinics…

Topics:

Tuberculosis (TB)

Countries:

Cameroon,

Kenya

Journal Articles

Tuberculosis Infection in Children and Adolescents

Published October 31, 2024

The burden of tuberculosis (TB) in children and adolescents remains very significant. Several million children and adolescents are infected with TB each year worldwide following exposure to an infectious TB case and the risk of progression from TB infection to tuberculosis disease is higher in this group compared to adults.

Topics:

Tuberculosis (TB)

Journal Articles

Follow-Up Outcomes of Children, Adolescents, and Young People on Darunavir-Based Third-Line Antiretroviral Therapy

Published October 30, 2024

Background: We assessed clinical outcomes among children, adolescents, and people younger than 25 years on darunavir-based antiretroviral therapy (ART) in 9 sub-Saharan African countries. Setting: Third-line ART centers in Cameroon, Eswatini, Kenya, Lesotho, Nigeria, Rwanda, Uganda, Zambia, and Zimbabwe. Methods: From January 2019 to December 2022, we collected data from a cohort of…

Topics:

Adolescents,

Pediatric HIV

Countries:

Cameroon,

Eswatini,

Kenya,

Lesotho,

Nigeria,

Rwanda,

Uganda,

Zambia,

Zimbabwe

Journal Articles

Decentralisation and integration of paediatric tuberculosis services to primary healthcare facilities as an approach to optimise management in Cameroon and Kenya

Published October 30, 2024

Introduction: Tuberculosis (TB) remains a major cause of morbidity and mortality for children less than 5 years. Diagnosis and treatment of children with active TB is often centralised in district hospital settings due to poor public health infrastructure and lack of diagnostic capabilities in primary healthcare (PHC) facilities. This analysis…

Topics:

Tuberculosis (TB)

Countries:

Cameroon,

Kenya

Little girl's hands

Issue Briefs

Building Trust for Global Health

Published October 2, 2024

Most causes of deaths in children could be prevented with effective treatment and interventions that are feasible for implementation, even in resource-constrained settings. However, appropriate medicines to save and improve the lives of infants and children often do not exist, are unavailable, or are not quality assured. This puts children’s…

Topics:

HIV,

Pediatric HIV

Issue Briefs

Building a Future of Health

Published October 2, 2024

An Unspoken Crisis: Children Are Being Left Behind In 2022, one child died every six seconds. The causes of most of those deaths were preventable. This is unacceptable. Whereas countries have the tools and knowledge to end preventable deaths and suffering in children, children face inequalities in access to health…

Topics:

Pediatric HIV,

Tuberculosis (TB)

Resource

Looking Forward

Published September 15, 2024

Topics:

Adolescents,

Pediatric HIV,

Prevention of Mother-to-Child Transmission (PMTCT)

Journal Articles

Effect of COVID-19 on Paediatric TB Service Delivery and Patients’ Comfort Receiving TB Services in Cameroon and Kenya During COVID

Published August 25, 2024

Background The outbreak of COVID-19 has caused a setback to the gains achieved in tuberculosis (TB) control by impairing TB diagnosis, delaying treatment initiation and aggravating TB deaths. This study explored the effect of COVID-19 on paediatric TB services provided through the Catalysing Paediatric TB Innovations (CaP-TB) project among caregivers…

Topics:

Global Health Security,

Tuberculosis (TB)

Countries:

Cameroon,

Kenya